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Article

Thiazide-sensitive Na+-Cl- cotransporter: genetic polymorphisms and human diseases.

Acta biochimica et biophysica Sinica - 1 May 2015

Wang Linghong, Dong Chao, Xi Ya-Guang, Su Xiulan

Abstract excerpt

The thiazide-sensitive Na(+)-Cl(-) cotransporter (TSC) is responsible for the major sodium chloride reabsorption pathway, which is located in the apical membrane of the epithelial cells of the distal convoluted tubule. TSC is involved in several physiological activities including transepithelial ion absorption and secretion, cell volume regulation, and setting intracellular Cl(-) concentration below or above its...

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Source

Identifiers

PMID: 25841442
DOI: 10.1093/abbs/gmv020

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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