Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Molecular insights from dysregulation of the thiazide-sensitive WNK/SPAK/NCC pathway in the kidney: Gordon syndrome and thiazide-induced hyponatraemia.

Clinical and experimental pharmacology & physiology - 1 Dec 2013

Glover Mark, O'Shaughnessy Kevin M

Abstract excerpt

Human blood pressure is dependent on balancing dietary salt intake with its excretion by the kidney. Mendelian syndromes of altered blood pressure demonstrate the importance of the distal nephron in this process and of the thiazide-sensitive pathway in particular. Gordon syndrome (GS), the phenotypic inverse of the salt-wasting Gitelman syndrome, is a condition of hyperkalaemic hypertension that is reversed by...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Diuretics
Share to Gitelman Syndrome

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Minor Histocompatibility Antigens

Share to Pseudohypoaldosteronism

Share to Receptors, Drug

Share to Sodium

Share to Sodium Chloride Symporters

Share to WNK Lysine-Deficient Protein Kinase 1

Source

Identifiers

PMID: 23683032
DOI: 10.1111/1440-1681.12115

Genes

CUL3
KLHL3
WNK1
WNK4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Molecular insights from dysregulation of the thiazide-sensitive WNK/SPAK/NCC pathway in the kidney: Gordon syndrome and thiazide-induced hyponatraemia.PMID 23683032Read ↗

Gitelman & Gordon : mirror image syndromes reveal the roles of WNKs in blood pressure homeostasis and novel anti-hypertensive targetsSemantic proximity Read ↗

Regulation of the renal NaCl cotransporter by the WNK/SPAK pathway: lessons learned from genetically altered animals.Semantic proximity Read ↗

WNK Kinases, Renal Ion Transport and HypertensionSemantic proximity Read ↗

Thiazide-induced hyponatraemia: epidemiology and clues to pathogenesis.Semantic proximity Read ↗

The Molecular Genetics of Gordon Syndrome.Semantic proximity Read ↗

Generation and analysis of pseudohypoaldosteronism type II knock-in mice caused by a nonsense KLHL3 mutation in the Kelch domain.Semantic proximity Read ↗

Detection of mutations in KLHL3 and CUL3 in families with FHHt (familial hyperkalaemic hypertension or Gordon's syndrome).Semantic proximity Read ↗

Bartter Syndromes and Other Salt-Losing TubulopathiesSemantic proximity Read ↗

Molecular variants of the thiazide-sensitive Na+-Cl- cotransporter in hypertensive families.Semantic proximity Read ↗

Thiazide-sensitive Na+-Cl- cotransporter: genetic polymorphisms and human diseases.Semantic proximity Read ↗

Mutation affecting the conserved acidic WNK1 motif causes inherited hyperkalemic hyperchloremic acidosis.Semantic proximity Read ↗

WNK kinases regulate thiazide-sensitive Na-Cl cotransport.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.