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Article

Non-association of the thiazide-sensitive Na,Cl-cotransporter gene with polygenic hypertension in both rats and humans.

Journal of hypertension - 1 Sept 2001

Song Y, Herrera V L, Filigheddu F, Troffa C, Lopez L V, Glorioso N, Ruiz-Opazo N

Abstract excerpt

OBJECTIVE: Genes underlying renal regulation of sodium and water balances are a priori valid candidates for polygenic hypertension susceptibility genes. Having recently identified the association of alpha1 Na,K-ATPase (ATP1A1) and Na,K,2Cl-cotransporter (NKCC2) as interacting hypertension susceptibility loci in both a rat model and human hypertensives, we investigated whether the thiazide-sensitive...

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PMID: 11564973
DOI: 10.1097/00004872-200109000-00005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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