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Article

G2736A polymorphism of thiazide-sensitive Na-Cl cotransporter gene predisposes to hypertension in young women.

Journal of hypertension - 1 Nov 2004

Matsuo Akiko, Katsuya Tomohiro, Ishikawa Kazuhiko, Sugimoto Ken, Iwashima Yoshio, Yamamoto Koichi, Ohishi Mitsuru, Rakugi Hiromi, Ogihara Toshio

Abstract excerpt

OBJECTIVE: The thiazide-sensitive Na-Cl cotransporter (TSC) is located in the distal renal tubules. Several mutations of the TSC gene cause Gitelman's syndrome, which is an autosomal recessive disease characterized by low blood pressure and hypokalemia. Recently, an association between TSC gene polymorphisms (Arg904Gln, G2736A; Thr465Thr, C1420T; Gly264Ala, G816C) and essential hypertension has been reported in...

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PMID: 15480096
DOI: 10.1097/00004872-200411000-00014

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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