Article
A single nucleotide polymorphism alters the activity of the renal Na+:Cl- cotransporter and reveals a role for transmembrane segment 4 in chloride and thiazide affinity.
The Journal of biological chemistry - 16 Apr 2004
Moreno Erika, Tovar-Palacio Claudia, de los Heros Paola, Guzmán Blanca, Bobadilla Norma A, Vázquez Norma, Riccardi Daniela, Poch Esteban, Gamba Gerardo
Abstract excerpt
The thiazide-sensitive Na+:Cl- cotransporter is the major salt transport pathway in the distal convoluted tubule of the kidney, and a role of this cotransporter in blood pressure homeostasis has been defined by physiological studies on pressure natriuresis and by its involvement in monogenic diseases that feature arterial hypotension or hypertension. Data base analysis revealed that 135 single nucleotide...
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