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Article

Identification of 108 SNPs in TSC, WNK1, and WNK4 and their association with hypertension in a Japanese general population.

Journal of human genetics - 1 Jan 2004

Kokubo Yoshihiro, Kamide Kei, Inamoto Nozomu, Tanaka Chihiro, Banno Mariko, Takiuchi Shin, Kawano Yuhei, Tomoike Hitonobu, Miyata Toshiyuki

Abstract excerpt

The deletion of thiazide-sensitive Na-Cl cotransporter ( TSC, SLC12A3) causes Gitelman's syndrome characterized by low blood pressure, while deletions of the WNK1 ( PRKWNK1) and WNK4 ( PRKWNK4) genes cause familial hypertension known as pseudohypoaldosteronism type II. Recent studies have revealed that cell surface expression of TSC is regulated by WNK1 and WNK4. We hypothesized that molecular variations in TSC,...

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Identifiers

PMID: 15309683
DOI: 10.1007/s10038-004-0181-0

Genes

WNK4
WNK1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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