The thiazide-sensitive Na(+)-Cl(-) cotransporter gene, C1784T, and adrenergic receptor-beta3 gene, T727C, may be gene polymorphisms susceptible to the antihypertensive effect of thiazide diuretics.

doi:10.1291/hypres.27.821

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

The thiazide-sensitive Na(+)-Cl(-) cotransporter gene, C1784T, and adrenergic receptor-beta3 gene, T727C, may be gene polymorphisms susceptible to the antihypertensive effect of thiazide diuretics.

Hypertension research : official journal of the Japanese Society of Hypertension - 1 Nov 2004

Matayoshi Tetsutaro, Kamide Kei, Takiuchi Shin, Yoshii Masayoshi, Miwa Yoshikazu, Takami Yoichi, Tanaka Chihiro, Banno Mariko, Horio Takeshi, Nakamura Satoko, Nakahama Hajime, Yoshihara Fumiki, Inenaga Takashi, Miyata Toshiyuki, Kawano Yuhei

Abstract excerpt

The response of blood pressure to thiazide diuretics (TZDs) differs among individuals. The prediction of the antihypertensive effect of TZDs is important for realizing individualized therapy in the management of hypertension. The aim of this study was to identify the single nucleotide polymorphisms (SNPs) susceptible to the antihypertensive effect of TZDs, particularly focusing on genes related to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Diuretics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hypertension, Renal

Share to Receptors, Mineralocorticoid

Share to Sodium-Calcium Exchanger

Share to Sodium Chloride Symporters

Share to Solute Carrier Family 12, Member 3

Share to Sympathetic Nervous System

Share to WNK Lysine-Deficient Protein Kinase 1

Source

Open in PubMed

Identifiers

PMID: 15824464
DOI: 10.1291/hypres.27.821

Genes

ADRB3
WNK1
WNK4
ACE
ADD1
ADRB1
ADRB2
AGT
AGTR1
GNB3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The thiazide-sensitive Na(+)-Cl(-) cotransporter gene, C1784T, and adrenergic receptor-beta3 gene, T727C, may be gene polymorphisms susceptible to the antihypertensive effect of thiazide diuretics.PMID 15824464Read ↗

G2736A polymorphism of thiazide-sensitive Na-Cl cotransporter gene predisposes to hypertension in young women.Semantic proximity Read ↗

Genetic predictors of thiazide-induced serum potassium changes in nondiabetic hypertensive patients.Semantic proximity Read ↗

Thiazide-induced hyponatraemia: epidemiology and clues to pathogenesis.Semantic proximity Read ↗

WNK1 kinase polymorphism and blood pressure response to a thiazide diuretic.Semantic proximity Read ↗

Thiazide-sensitive Na+-Cl- cotransporter: genetic polymorphisms and human diseases.Semantic proximity Read ↗

Genetic variation in renin predicts the effects of thiazide diuretics.Semantic proximity Read ↗

[Association of thiazide-sensitive Na+-Cl* cotransporter gene polymorphisms with the risk of essential hypertension].Semantic proximity Read ↗

Molecular variants of the thiazide-sensitive Na+-Cl- cotransporter in hypertensive families.Semantic proximity Read ↗

Association study of variants in two ion-channel genes (TSC and CLCNKB) and hypertension in two ethnic groups in Northwest China.Semantic proximity Read ↗

Identification of 108 SNPs in TSC, WNK1, and WNK4 and their association with hypertension in a Japanese general population.Semantic proximity Read ↗

Association of variants in NEDD4L with blood pressure response and adverse cardiovascular outcomes in hypertensive patients treated with thiazide diuretics.Semantic proximity Read ↗

Genomic association analysis of common variants influencing antihypertensive response to hydrochlorothiazide.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.