Article
Endothelial LOX-1 activation differentially regulates arterial thrombus formation depending on oxLDL levels: role of the Oct-1/SIRT1 and ERK1/2 pathways.
Cardiovascular research - 1 Apr 2017
Akhmedov Alexander, Camici Giovanni G, Reiner Martin F, Bonetti Nicole R, Costantino Sarah, Holy Erik W, Spescha Remo D, Stivala Simona, Schaub Clerigué Ariane, Speer Thimoteus, Breitenstein Alexander, Manz Jasmin, Lohmann Christine, Paneni Francesco, Beer Juerg-Hans, Lüscher Thomas F
Abstract excerpt
AIMS: The lectin-like oxLDL receptor-1 (LOX-1) promotes endothelial uptake of oxidized low-density lipoprotein (oxLDL) and plays an important role in atherosclerosis and acute coronary syndromes (ACS). However, its role in arterial thrombus formation remains unknown. We investigated whether LOX-1 plays a role in arterial thrombus formation in vivo at different levels of oxLDL using endothelial-specific LOX-1...
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