Article

Heme induces mRNA expression and activation of tissue factor by TLR4 dependent mechanisms

2020-10-13

Abstract excerpt

<h4>Introduction</h4> Hemolytic diseases such as Sickle Cell Disease (SCD) are characterized by a natural propensity for both arterial and venous thrombosis. Evidence showing that heme can induce tissue factor (TF) expression in endothelial cells and TF-dependent coagulation activation in animal models of SCD suggest that heme can contribute to hypercoagulability in this condition. We recently demonstrated that he...

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Literature Corpus work: fefbca8c-e785-5473-be6c-edfd695eadc2
DOI: 10.1101/2020.10.09.20210336

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