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Article

The role of heme oxygenase-1 in pulmonary disease.

American journal of respiratory cell and molecular biology - 1 Feb 2007

Fredenburgh Laura E, Perrella Mark A, Mitsialis S Alex

Abstract excerpt

Heme oxygenase (HO)-1, the inducible isoform of heme oxygenase, is a cytoprotective enzyme that plays a central role in the defense against oxidative and inflammatory insults in the lung. HO-1 catalyzes the degradation of heme, a potent oxidant, into biliverdin, iron, and carbon monoxide (CO). These downstream products of heme catabolism have recently been found to mediate the antioxidant, antiapoptotic,...

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Identifiers

PMID: 16980551
DOI: 10.1165/rcmb.2006-0331TR
PMCID: PMC2176110

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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