Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

USF1 and dyslipidemias: converging evidence for a functional intronic variant.

Human molecular genetics - 1 Sept 2005

Naukkarinen Jussi, Gentile Massimiliano, Soro-Paavonen Aino, Saarela Janna, Koistinen Heikki A, Pajukanta Päivi, Taskinen Marja-Riitta, Peltonen Leena

Abstract excerpt

Upstream transcription factor 1 (USF1), the first gene associated with familial combined hyperlipidemia (FCHL), regulates numerous genes of glucose and lipid metabolism. Phenotypic overlap between FCHL, type 2 diabetes and the metabolic syndrome makes this gene an intriguing candidate in the disease process of these traits as well. As no disease-associated mutations in the coding region of USF1 have been...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA-Binding Proteins
Share to Gene Expression Regulation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hyperlipidemias

Share to Introns

Share to Sequence Alignment

Share to Sequence Homology, Nucleic Acid

Share to Transcription Factors

Share to Upstream Stimulatory Factors

Source

Identifiers

PMID: 16076849
DOI: 10.1093/hmg/ddi294

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

USF1 and dyslipidemias: converging evidence for a functional intronic variant.PMID 16076849Read ↗

Functional variant disrupts insulin induction of USF1: mechanism for USF1-associated dyslipidemias.Semantic proximity Read ↗

USF1 contributes to high serum lipid levels in Dutch FCHL families and U.S. whites with coronary artery disease.Semantic proximity Read ↗

Genetics of familial combined hyperlipidemiaSemantic proximity Read ↗

Familial combined hyperlipidemia is associated with upstream transcription factor 1 (USF1).Semantic proximity Read ↗

Variation in USF1 shows haplotype effects, gene : gene and gene : environment associations with glucose and lipid parameters in the European Atherosclerosis Research Study II.Semantic proximity Read ↗

USF1 gene variants, cardiovascular risk, and mortality in European Americans: analysis of two US cohort studies.Semantic proximity Read ↗

Upstream transcription factor 1 (USF1) in risk of type 2 diabetes: association study in 2000 Dutch Caucasians.Semantic proximity Read ↗

Familial combined hyperlipidemia in Mexicans: association with upstream transcription factor 1 and linkage on chromosome 16q24.1.Semantic proximity Read ↗

Upstream stimulatory factor 1 associated with familial combined hyperlipidemia, LDL cholesterol, and triglycerides.Semantic proximity Read ↗

Genetic variants in the USF1 gene are associated with low-density lipoprotein cholesterol levels and incident type 2 diabetes mellitus in women: results from the MONICA/KORA Augsburg case-cohort study, 1984-2002.Semantic proximity Read ↗

Genetic association and interaction analysis of USF1 and APOA5 on lipid levels and atherosclerosis.Semantic proximity Read ↗

Upstream Transcription Factor 1 (USF1) allelic variants regulate lipoprotein metabolism in women and USF1 expression in atherosclerotic plaque.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.