Article
Risk alleles of USF1 gene predict cardiovascular disease of women in two prospective studies.
PLoS genetics - 1 May 2006
Komulainen Kati, Alanne Mervi, Auro Kirsi, Kilpikari Riika, Pajukanta Päivi, Saarela Janna, Ellonen Pekka, Salminen Kaisa, Kulathinal Sangita, Kuulasmaa Kari, Silander Kaisa, Salomaa Veikko, Perola Markus, Peltonen Leena
Abstract excerpt
Upstream transcription factor 1 (USF1) is a ubiquitously expressed transcription factor controlling several critical genes in lipid and glucose metabolism. Of some 40 genes regulated by USF1, several are involved in the molecular pathogenesis of cardiovascular disease (CVD). Although the USF1 gene has been shown to have a critical role in the etiology of familial combined hyperlipidemia, which predisposes to...
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