Article
Variation in USF1 shows haplotype effects, gene : gene and gene : environment associations with glucose and lipid parameters in the European Atherosclerosis Research Study II.
Human molecular genetics - 1 Aug 2004
Putt Wendy, Palmen Jutta, Nicaud Viviane, Tregouet David-Alexandre, Tahri-Daizadeh Nadia, Flavell David M, Humphries Steve E, Talmud Philippa J
Abstract excerpt
Upstream stimulatory factor 1 (USF 1), is a transcription factor controlling expression of several genes involved in lipid and glucose homeostasis and co-localizes with familial combined hyperlipidemia (FCHL) and type 2 diabetes on chromosome 1q22-23. We sequenced USF1 in 24 UK FCHL probands, but found no rare or common cSNPs. Three common intronic single nucleotide ploymorphisms (SNP), 306A>G, 475C>T and...
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