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Article

Alpha7 nicotinic acetylcholine receptor mRNA expression and binding in postmortem human brain are associated with genetic variation in neuregulin 1.

Human molecular genetics - 1 Dec 2007

Mathew Shiny V, Law Amanda J, Lipska Barbara K, Dávila-García Martha I, Zamora Eduardo D, Mitkus Shruti N, Vakkalanka Radhakrishna, Straub Richard E, Weinberger Daniel R, Kleinman Joel E, Hyde Thomas M

Abstract excerpt

Studies in cell culture and in animals suggest that neuregulin 1 (NRG1), a probable schizophrenia susceptibility gene, regulates the expression of the alpha7 nicotinic acetylcholine receptors (nAChRs). We hypothesized that schizophrenia-associated allelic variations within the NRG1 gene, via their effects on NRG1 isoform expression, would be associated with alterations in nAChR alpha7 receptor levels. We examined...

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Identifiers

PMID: 17884806
DOI: 10.1093/hmg/ddm253

Genes

NRG1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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