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Article

Elevated peripheral expression of neuregulin-1 (NRG1) mRNA isoforms in clozapine-treated schizophrenia patients.

Translational psychiatry - 11 Dec 2017

Mostaid Md Shaki, Lee Ting Ting, Chana Gursharan, Sundram Suresh, Shannon Weickert Cynthia, Pantelis Christos, Everall Ian, Bousman Chad

Abstract excerpt

Differential expression of neuregulin-1 (NRG1) mRNA isoforms and proteins has been reported in schizophrenia, primarily in post-mortem brain tissue. In this study, we examined 12 NRG1 SNPs, eight NRG1 mRNA isoforms (type I, type I(Ig2), type II, type III, type IV, EGFα, EGFβ, pan-NRG1) in whole blood, and NRG1-β1 protein in serum of clozapine-treated schizophrenia patients (N = 71) and healthy controls (N = 57)....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29225331
DOI: 10.1038/s41398-017-0041-2
PMCID: PMC5802529

Genes

NRG1

Provenance

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