Regulation of alpha7-nicotinic receptor subunit and alpha7-like gene expression in the prefrontal cortex of patients with bipolar disorder and schizophrenia.

doi:10.1111/j.1600-0447.2006.00785.x

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Article

Regulation of alpha7-nicotinic receptor subunit and alpha7-like gene expression in the prefrontal cortex of patients with bipolar disorder and schizophrenia.

Acta psychiatrica Scandinavica - 1 Sept 2006

De Luca V, Likhodi O, Van Tol H H M, Kennedy J L, Wong A H C

Abstract excerpt

OBJECTIVE: The alpha7-nicotinic receptor subunit gene (CHRNA7) is located at chromosome 15q13-14, a region previously linked with schizophrenia. Genetic association and mRNA expression studies also implicate CHRNA7 in schizophrenia. The CHRNA7 gene has a partial duplication that constitutes the alpha7-like nicotinic receptor gene (CHRFAM7A). We hypothesized that major psychoses could affect the expression of both...

Topics

Adult
Bipolar Disorder
Chromosomes, Human, Pair 15
Female
Gene Duplication
Gene Expression
Genetic Predisposition to Disease
Humans
Male
Middle Aged
Prefrontal Cortex

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

RNA, Messenger

Receptors, Nicotinic

Reference Values

Risk Factors

Schizophrenia

Statistics as Topic

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Open in PubMed

Identifiers

PMID: 16889592
DOI: 10.1111/j.1600-0447.2006.00785.x

Genes

CHRNA7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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Regulation of alpha7-nicotinic receptor subunit and alpha7-like gene expression in the prefrontal cortex of patients with bipolar disorder and schizophrenia.PMID 16889592Read ↗

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