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Article

Transcriptomic Analysis Shows Decreased Cortical Expression of NR4A1, NR4A2 and RXRB in Schizophrenia and Provides Evidence for Nuclear Receptor Dysregulation.

PloS one - 1 Jan 2016

Corley Susan M, Tsai Shan-Yuan, Wilkins Marc R, Shannon Weickert Cynthia

Abstract excerpt

Many genes are differentially expressed in the cortex of people with schizophrenia, implicating factors that control transcription more generally. Hormone nuclear receptors dimerize to coordinate context-dependent changes in gene expression. We hypothesized that members of two families of nuclear receptors (NR4As), and retinoid receptors (RARs and RXRs), are altered in the dorsal lateral prefrontal cortex (DLPFC)...

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Identifiers

PMID: 27992436
DOI: 10.1371/journal.pone.0166944
PMCID: PMC5161508

Genes

KLF4
RXRB
RARG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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