Article
A family-based association study and gene expression analyses of netrin-G1 and -G2 genes in schizophrenia.
Biological psychiatry - 15 Feb 2005
Aoki-Suzuki Mika, Yamada Kazuo, Meerabux Joanne, Iwayama-Shigeno Yoshimi, Ohba Hisako, Iwamoto Kazuya, Takao Hitomi, Toyota Tomoko, Suto Yumiko, Nakatani Noriaki, Dean Brian, Nishimura Sachiko, Seki Kenjiro, Kato Tadafumi, Itohara Shigeyoshi, Nishikawa Toru, Yoshikawa Takeo
Abstract excerpt
BACKGROUND: The netrin-G1 (NTNG1) and -G2 (NTNG2) genes, recently cloned from mouse, play a role in the formation and/or maintenance of glutamatergic neural circuitry. Accumulating evidence strongly suggests that disturbances of neuronal development and the N-methyl-d-aspartate receptor-mediated signaling system might represent a potential pathophysiology in schizophrenia. We therefore set out to examine the...
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