Article
Neuregulin 1 transcripts are differentially expressed in schizophrenia and regulated by 5' SNPs associated with the disease.
Proceedings of the National Academy of Sciences of the United States of America - 25 Apr 2006
Law Amanda J, Lipska Barbara K, Weickert Cynthia Shannon, Hyde Thomas M, Straub Richard E, Hashimoto Ryota, Harrison Paul J, Kleinman Joel E, Weinberger Daniel R
Abstract excerpt
Genetic variation in neuregulin 1 (NRG1) is associated with schizophrenia. The disease-associated SNPs are noncoding, and their functional implications remain unknown. We hypothesized that differential expression of the NRG1 gene explains its association to the disease. We examined four of the di...
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