Article
Elevated expression and polymorphisms of SOCS3 influence patient response to antiviral therapy in chronic hepatitis C.
Gut - 1 Apr 2008
Persico M, Capasso M, Russo R, Persico E, Crocè L, Tiribelli C, Iolascon A
Abstract excerpt
BACKGROUND: The response to antiviral therapy of chronic hepatitis C virus (HCV) infection is determined by virological, environmental and genetic factors. OBJECTIVE: The hypothesis was tested that the expression of specific genes and their haplotype frequencies can differentiate between non-responders (NRs) and sustained virological responders (SVRs) to antiviral treatment. METHODS: A methodological approach...
Topics
- Adult
- Aged
- Antiviral Agents
- Biomarkers
- Cell Line, Transformed
- Drug Therapy, Combination
- Female
- Gene Expression Profiling
- Genetic Markers
- Haplotypes
- Hepatitis C, Chronic
- Humans
- Interferon-alpha
- Male