The impact of IL28B genotype on the gene expression profile of patients with chronic hepatitis C treated with pegylated interferon alpha and ribavirin.

doi:10.1186/1479-5876-10-25

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Article

The impact of IL28B genotype on the gene expression profile of patients with chronic hepatitis C treated with pegylated interferon alpha and ribavirin.

Journal of translational medicine - 7 Feb 2012

Younossi Zobair M, Birerdinc Aybike, Estep Mike, Stepanova Maria, Afendy Arian, Baranova Ancha

Abstract excerpt

BACKGROUND: Recent studies of CH-C patients have demonstrated a strong association between IL28B CC genotype and sustained virologic response (SVR) after PEG-IFN/RBV treatment. We aimed to assess whether IL28B alleles rs12979860 genotype influences gene expression in response to PEG-IFN/RBV in CH-C patients. METHODS: Clinical data and gene expression data were available for 56 patients treated with PEG-IFN/RBV....

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PMID: 22313623
DOI: 10.1186/1479-5876-10-25
PMCID: PMC3296607

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SOCS1

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The impact of IL28B genotype on the gene expression profile of patients with chronic hepatitis C treated with pegylated interferon alpha and ribavirin.PMID 22313623Read ↗

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