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Article

Hepatic SOCS3 expression is strongly associated with non-response to therapy and race in HCV and HCV/HIV infection.

Journal of hepatology - 1 Apr 2009

Kim Kyung-Ah, Lin Wenyu, Tai Andrew W, Shao Run-Xuan, Weinberg Ethan, De Sa Borges Carolina B, Bhan Atul K, Zheng Hui, Kamegaya Yoshitaka, Chung Raymond T

Abstract excerpt

BACKGROUND/AIMS: The response rates of HCV infection to interferon therapy vary depending on viral and host factors. We hypothesized that key regulators of the IFN signaling pathway are predictive of treatment outcome. METHODS: We measured the expression of signal transducer and activator of transcription 1 (STAT1) and suppressor of cytokine signaling 3 (SOCS3) in pretreatment liver biopsies. Staining...

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Source

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Identifiers

PMID: 19231005
DOI: 10.1016/j.jhep.2008.12.021
PMCID: PMC3146466

Genes

SOCS3
STAT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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