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Article

Suppressor of cytokine signaling 3 (SOCS3) expression and hepatitis C virus-related chronic hepatitis: Insulin resistance and response to antiviral therapy.

Hepatology (Baltimore, Md.) - 1 Oct 2007

Persico Marcello, Capasso Mario, Persico Eliana, Svelto Monica, Russo Roberta, Spano Daniela, Crocè Lori, La Mura Vincenzo, Moschella Francesco, Masutti Flora, Torella Roberto, Tiribelli Claudio, Iolascon Achille

Abstract excerpt

UNLABELLED: The response to antiviral therapy is lower in hepatitis C virus (HCV) patients with genotype 1 than in those with genotype 2. Overexpression of the suppressor of cytokine signaling 3 (SOCS3) gene in liver tissue is associated with a poorer treatment outcome in patients with chronic hepatitis C viral genotype 1. Also, insulin resistance has been implicated in nonresponse to an anti-HCV treatment. To...

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Identifiers

PMID: 17668875
DOI: 10.1002/hep.21782

Genes

SOCS3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Suppressor of cytokine signaling 3 (SOCS3) expression and hepatitis C virus-related chronic hepatitis: Insulin resistance and response to antiviral therapy.PMID 17668875Read ↗

Insulin resistance, adipokine profile and hepatic expression of SOCS-3 gene in chronic hepatitis C.Semantic proximity Read ↗

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Hepatic SOCS3 expression is strongly associated with non-response to therapy and race in HCV and HCV/HIV infection.Semantic proximity Read ↗

Elevated expression and polymorphisms of SOCS3 influence patient response to antiviral therapy in chronic hepatitis C.Semantic proximity Read ↗

Hepatitis C virus (HCV)-induced suppressor of cytokine signaling (SOCS) 3 regulates proinflammatory TNF-α responsesSemantic proximity Read ↗

Suppressor of Cytokine Signaling-3 Gene Polymorphisms and the Risk of Hepatocellular Carcinoma in Chronic Hepatitis C Patients in Egypt.Semantic proximity Read ↗

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Transcriptional response of MxA, PKR and SOCS3 to interferon-based therapy in HCV genotype 4-infected patients and contribution of p53 to host antiviral response.Semantic proximity Read ↗

Association of suppressor of cytokine signalling 3 polymorphisms with insulin resistance in patients with chronic hepatitis C.Semantic proximity Read ↗

Suppressor of Cytokine Signaling-3 (SOCS-3) Induces Proprotein Convertase Subtilisin Kexin Type 9 (PCSK9) Expression in Hepatic HepG2 Cell Line.Semantic proximity Read ↗

Both type I and II IFN induce insulin resistance by inducing different isoforms of SOCS expression in 3T3-L1 adipocytesSemantic proximity Read ↗

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