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Cell Culture Adaptation of Hepatitis C Virus and In Vivo Viability of an Adapted Variant

20 Sept 2007

Abstract excerpt

Production of infectious hepatitis C virus in cell culture has become possible because of the unique properties of the JFH1 isolate. However, virus titers are rather low, limiting the utility of this system. Here we describe the generation of cell culture-adapted JFH1 variants yielding higher titers of infectious particles and enhanced spread of infection in cultured cells. Sequence analysis of adapted genomes...

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PMID: 17881454
DOI: 10.1128/jvi.01362-07

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