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Article

Novel mutations in a tissue culture-adapted hepatitis C virus strain improve infectious-virus stability and markedly enhance infection kinetics.

Journal of virology - 1 Apr 2011

Pokrovskii Maria V, Bush Caroline O, Beran Rudolf K F, Robinson Margaret F, Cheng Guofeng, Tirunagari Neeraj, Fenaux Martijn, Greenstein Andrew E, Zhong Weidong, Delaney William E, Paulson Matthew S

Abstract excerpt

Hepatitis C virus (HCV) establishes persistent infections and leads to chronic liver disease. It only recently became possible to study the entire HCV life cycle due to the ability of a unique cloned patient isolate (JFH-1) to produce infectious particles in tissue culture. However, despite efficient RNA replication, yields of infectious virus particles remain modest. This presents a challenge for large-scale...

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Identifiers

PMID: 21289124
DOI: 10.1128/JVI.01760-10
PMCID: PMC3126117

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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