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Article

A cell culture adapted HCV JFH1 variant that increases viral titers and permits the production of high titer infectious chimeric reporter viruses.

PloS one - 1 Jan 2012

Liu Shuanghu, Xiao Li, Nelson Cassie, Hagedorn Curt H, Hagedorn Curt

Abstract excerpt

The unique properties of the hepatitis C virus (HCV) JFH1 isolate have made it possible to produce and study HCV in an infectious cell culture system. However, relatively low virus titers restrict some of the uses of this system and preparing infectious chimeric reporter viruses have been difficult. In this study, we report cell culture-adapted mutations in wild-type JFH1 yielding higher titers of infectious...

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Identifiers

PMID: 23028707
DOI: 10.1371/journal.pone.0044965
PMCID: PMC3441746

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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