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Article

Hepatitis C virus JFH-1 strain infection in chimpanzees is associated with low pathogenicity and emergence of an adaptive mutation.

Hepatology (Baltimore, Md.) - 1 Sept 2008

Kato Takanobu, Choi Youkyung, Elmowalid Gamal, Sapp Ronda K, Barth Heidi, Furusaka Akihiro, Mishiro Shunji, Wakita Takaji, Krawczynski Krzysztof, Liang T Jake

Abstract excerpt

UNLABELLED: The identification of the hepatitis C virus (HCV) strain JFH-1 enabled the successful development of infectious cell culture systems. Although this strain replicates efficiently and produces infectious virus in cell culture, the replication capacity and pathogenesis in vivo are still undefined. To assess the in vivo phenotype of the JFH-1 virus, cell culture-generated JFH-1 virus (JFH-1cc) and patient...

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Identifiers

PMID: 18712792
DOI: 10.1002/hep.22422
PMCID: PMC2535917

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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