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Article

Efficient production of infectious hepatitis C virus with adaptive mutations in cultured hepatoma cells.

The Journal of general virology - 1 Jul 2009

Bungyoku Yasuaki, Shoji Ikuo, Makine Tatsuhiko, Adachi Tetsuya, Hayashida Kazumi, Nagano-Fujii Motoko, Ide Yoshi-Hiro, Deng Lin, Hotta Hak

Abstract excerpt

Robust production of infectious hepatitis C virus (HCV) in cell culture was realized by using the JFH1 strain and the homologous chimeric J6/JFH1 strain in Huh-7.5 cells, a highly HCV-permissive subclone of Huh-7 cells. In this study, we aimed to establish a more efficient HCV-production system and to gain some insight into the adaptation mechanisms of efficient HCV production. By serial passaging of...

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Identifiers

PMID: 19282429
DOI: 10.1099/vir.0.010983-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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