Article
Efficient culture adaptation of hepatitis C virus recombinants with genotype-specific core-NS2 by using previously identified mutations.
Journal of virology - 1 Mar 2011
Scheel Troels K H, Gottwein Judith M, Carlsen Thomas H R, Li Yi-Ping, Jensen Tanja B, Spengler Ulrich, Weis Nina, Bukh Jens
Abstract excerpt
Hepatitis C virus (HCV) is an important cause of chronic liver disease, and interferon-based therapy cures only 40 to 80% of patients, depending on HCV genotype. Research was accelerated by genotype 2a (strain JFH1) infectious cell culture systems. We previously developed viable JFH1-based recombinants encoding the structural proteins (core, E1, E2), p7, and NS2 of prototype isolates of the seven major HCV...
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