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Article

Almost total protection from age-related macular degeneration by haplotypes of the Regulators of Complement Activation.

Genomics - 1 Dec 2011

Williamson Joseph F, McLure Craig A, Guymer Robyn H, Baird Paul N, Millman John, Cantsilieris Stuart, Dawkins Roger L

Abstract excerpt

Age-related macular degeneration (AMD) is the leading cause of blindness in developed countries. It has been proposed that the polymorphism encoding Y402H (T1277C) in the complement factor H gene (CFH) is one of the main determinants of disease. We genotyped the polymorphism at a number of loci in the region encompassing the Regulators of Complement Activation (RCA) on chromosome 1, including T1277C SNP, in 187...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 21855625
DOI: 10.1016/j.ygeno.2011.08.002

Genes

CFH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Almost total protection from age-related macular degeneration by haplotypes of the Regulators of Complement Activation.PMID 21855625Read ↗

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