Article
Lack of MEF2A Delta7aa mutation in Irish families with early onset ischaemic heart disease, a family based study.
BMC medical genetics - 27 Jul 2006
Horan Paul G, Allen Adrian R, Hughes Anne E, Patterson Chris C, Spence Mark, McGlinchey Paul G, Belton Christine, Jardine Tracy C L, McKeown Pascal P
Abstract excerpt
BACKGROUND: Ischaemic heart disease (IHD) is a complex disease due to the combination of environmental and genetic factors. Mutations in the MEF2A gene have recently been reported in patients with IHD. In particular, a 21 base pair deletion (Delta7aa) in the MEF2A gene was identified in a family with an autosomal dominant pattern of inheritance of IHD. We investigated this region of the MEF2A gene using an Irish...
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