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Article

Role of inositol 1,4,5-trisphosphate receptors in apoptosis in DT40 lymphocytes.

The Journal of biological chemistry - 9 Nov 2007

Khan M Tariq, Bhanumathy Cunnigaiper D, Schug Zachary T, Joseph Suresh K

Abstract excerpt

The role of inositol 1,4,5-trisphosphate receptors (IP(3)R) in caspase-3 activation and cell death was investigated in DT40 chicken B-lymphocytes stably expressing various IP(3)R constructs. Both full-length type-I IP(3)R and a truncated construct corresponding to the caspase-3 cleaved "channel-only" fragment were able to support staurosporine (STS)-induced caspase-3 activation and cell death even when the IP(3)R...

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Identifiers

PMID: 17875645
DOI: 10.1074/jbc.M705183200

Genes

STS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Role of inositol 1,4,5-trisphosphate receptors in apoptosis in DT40 lymphocytes.PMID 17875645Read ↗

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