Article
Role of inositol 1,4,5-trisphosphate receptors in apoptosis in DT40 lymphocytes.
The Journal of biological chemistry - 9 Nov 2007
Khan M Tariq, Bhanumathy Cunnigaiper D, Schug Zachary T, Joseph Suresh K
Abstract excerpt
The role of inositol 1,4,5-trisphosphate receptors (IP(3)R) in caspase-3 activation and cell death was investigated in DT40 chicken B-lymphocytes stably expressing various IP(3)R constructs. Both full-length type-I IP(3)R and a truncated construct corresponding to the caspase-3 cleaved "channel-o...
Topics
- Animals
- Apoptosis
- Calcium
- Caspase 3
- Cell Line, Tumor
- Cell Survival
- Chickens
- Cytochromes c
- Cytosol
- Enzyme Activation
- Inositol 1,4,5-Trisphosphate Receptors
- Lymphocytes
- Membrane Potential, Mitochondrial
- Mutation
- Staurosporine