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Article

Acidocalcisomes of Trypanosoma brucei have an inositol 1,4,5-trisphosphate receptor that is required for growth and infectivity.

Proceedings of the National Academy of Sciences of the United States of America - 29 Jan 2013

Huang Guozhong, Bartlett Paula J, Thomas Andrew P, Moreno Silvia N J, Docampo Roberto

Abstract excerpt

Acidocalcisomes are acidic calcium stores rich in polyphosphate and found in a diverse range of organisms. The mechanism of Ca(2+) release from these organelles was unknown. Here we present evidence that Trypanosoma brucei acidocalcisomes possess an inositol 1,4,5-trisphosphate receptor (TbIP(3)R) for Ca(2+) release. Localization studies in cell lines expressing TbIP(3)R in its endogenous locus fused to an...

Topics

Animals
Blotting, Western
Calcium
Cell Line, Tumor
Inositol 1,4,5-Trisphosphate
Inositol 1,4,5-Trisphosphate Receptors
Mice
Mice, Inbred BALB C
Microscopy, Fluorescence
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Organelles

RNA Interference

Trypanosoma brucei brucei

Trypanosomiasis

Source

Open in PubMed Open full text

Identifiers

PMID: 23319604
DOI: 10.1073/pnas.1216955110
PMCID: PMC3562765

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-23319604-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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