Article
The inositol 1,4,5-trisphosphate receptor is required to signal autophagic cell death.
Molecular biology of the cell - 1 Feb 2008
Lam David, Kosta Artemis, Luciani Marie-Françoise, Golstein Pierre
Abstract excerpt
The signaling pathways governing pathophysiologically important autophagic (ACD) and necrotic (NCD) cell death are not entirely known. In the Dictyostelium eukaryote model, which benefits from both unique analytical and genetic advantages and absence of potentially interfering apoptotic machinery, the differentiation factor DIF leads from starvation-induced autophagy to ACD, or, if atg1 is inactivated, to NCD....
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