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Article

Expression of functional receptor-coupled TRPC3 channels in DT40 triple receptor InsP3 knockout cells.

The Journal of biological chemistry - 7 Sept 2001

Venkatachalam K, Ma H T, Ford D L, Gill D L

Abstract excerpt

The TRPC3 channel, an intensively studied member of the widely expressed transient receptor potential (TRP) family, is a Ca(2+)-conducting channel activated in response to phospholipase C-coupled receptors. Despite scrutiny, the receptor-induced mechanism to activate TRPC3 channels remains unclear. Evidence indicates TRPC3 channels interact directly with intracellular inositol 1,4,5-trisphosphate receptors...

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Source

Identifiers

PMID: 11466302
DOI: 10.1074/jbc.C100321200

Genes

TRPC3
BCR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Expression of functional receptor-coupled TRPC3 channels in DT40 triple receptor InsP3 knockout cells.PMID 11466302Read ↗

Assessment of the role of the inositol 1,4,5-trisphosphate receptor in the activation of transient receptor potential channels and store-operated Ca2+ entry channels.Semantic proximity Read ↗

TRPC3 mediates T-cell receptor-dependent calcium entry in human T-lymphocytes.Semantic proximity Read ↗

A calmodulin/inositol 1,4,5-trisphosphate (IP3) receptor-binding region targets TRPC3 to the plasma membrane in a calmodulin/IP3 receptor-independent process.Semantic proximity Read ↗

TRPC3: a multifunctional signaling molecule.Semantic proximity Read ↗

Role of inositol 1,4,5-trisphosphate receptors in apoptosis in DT40 lymphocytes.Semantic proximity Read ↗

TRPC3 controls agonist-stimulated intracellular Ca2+ release by mediating the interaction between inositol 1,4,5-trisphosphate receptor and RACK1.Semantic proximity Read ↗

Defining the stoichiometry of inositol 1,4,5-trisphosphate binding required to initiate Ca2+ release.Semantic proximity Read ↗

The Pro335 --> Leu polymorphism of type 3 inositol 1,4,5-trisphosphate receptor found in mouse inbred lines results in functional change.Semantic proximity Read ↗

Functional inositol 1,4,5-trisphosphate receptors assembled from concatenated homo- and heteromeric subunits.Semantic proximity Read ↗

Coupling Ca2+ store release to Icrac channel activation in B lymphocytes requires the activity of Lyn and Syk kinases.Semantic proximity Read ↗

An essential role of PI(4,5)P₂ for maintaining the activity of the transient receptor potential canonical (TRPC)4β.Semantic proximity Read ↗

Functional properties of the Drosophila melanogaster inositol 1,4,5-trisphosphate receptor mutants.Semantic proximity Read ↗

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