TLR3 deficiency in patients with herpes simplex encephalitis.

doi:10.1126/science.1139522

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Article

TLR3 deficiency in patients with herpes simplex encephalitis.

Science (New York, N.Y.) - 14 Sept 2007

Zhang Shen-Ying, Jouanguy Emmanuelle, Ugolini Sophie, Smahi Asma, Elain Gaëlle, Romero Pedro, Segal David, Sancho-Shimizu Vanessa, Lorenzo Lazaro, Puel Anne, Picard Capucine, Chapgier Ariane, Plancoulaine Sabine, Titeux Matthias, Cognet Céline, von Bernuth Horst, Ku Cheng-Lung, Casrouge Armanda, Zhang Xin-Xin, Barreiro Luis, Leonard Joshua, Hamilton Claire, Lebon Pierre, Héron Bénédicte, Vallée Louis, Quintana-Murci Lluis, Hovnanian Alain, Rozenberg Flore, Vivier Eric, Geissmann Frédéric, Tardieu Marc, Abel Laurent, Casanova Jean-Laurent

Abstract excerpt

Some Toll and Toll-like receptors (TLRs) provide immunity to experimental infections in animal models, but their contribution to host defense in natural ecosystems is unknown. We report a dominant-negative TLR3 allele in otherwise healthy children with herpes simplex virus 1 (HSV-1) encephalitis. TLR3 is expressed in the central nervous system (CNS), where it is required to control HSV-1, which spreads from the...

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PMID: 17872438
DOI: 10.1126/science.1139522

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TLR3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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