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Article

Polymorphisms in Toll-like receptor 3 confer natural resistance to human herpes simplex virus type 2 infection.

The Journal of general virology - 1 Aug 2012

Svensson Alexandra, Tunbäck Petra, Nordström Inger, Padyukov Leonid, Eriksson Kristina

Abstract excerpt

Lack of Toll-like receptor 3 (TLR3) functional activity predisposes children to human herpesvirus 1 (HSV-1) encephalitis. In this study, we have investigated whether there is any link between TLR3 and adult HSV-2 infection by studying genetic variations in TLR3. The frequency of four single-nucleotide polymorphisms (SNPs) in the TLR3 gene in 239 patients with genital HSV-2 infection and 162 healthy controls, as...

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Source

Identifiers

PMID: 22552940
DOI: 10.1099/vir.0.042572-0

Genes

TLR3

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