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Article

A case of neonatal herpes simplex virus type 2 encephalitis with TLR3 gene mutation and literature review.

Frontiers in neurology - 1 Jan 2026

Li Xiaojing, Chen Yali, Deng Chungui, Wang Dongmei, Qiu Jianwu

Abstract excerpt

Background: Neonatal herpes simplex virus type 2 (HSV-2) encephalitis frequently manifests with atypical clinical features, which complicates its early identification. Given the challenge of controlling the infant's seizures, whole exome sequencing was conducted to rule out genetic disorders like early-onset epileptic encephalopathy; this process incidentally revealed a variation in the TLR3 gene. Host genetic...

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Share to TLR3 gene
Share to Herpes Simplex
Share to Herpesvirus 2, Human

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Infant, Newborn

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Share to Pregnancy Complications, Infectious

Share to Toll-Like Receptor 3

Source

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Identifiers

PMID: 42620976
DOI: 10.3389/fneur.2026.1853080
PMCID: PMC13485870

Genes

TLR3

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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