Article
Loss of TLR3 aggravates CHIKV replication and pathology due to an altered virus-specific neutralizing antibody response.
EMBO molecular medicine - 1 Jan 2015
Her Zhisheng, Teng Terk-Shin, Tan Jeslin J L, Teo Teck-Hui, Kam Yiu-Wing, Lum Fok-Moon, Lee Wendy W L, Gabriel Christelle, Melchiotti Rossella, Andiappan Anand K, Lulla Valeria, Lulla Aleksei, Win Mar K, Chow Angela, Biswas Subhra K, Leo Yee-Sin, Lecuit Marc, Merits Andres, Rénia Laurent, Ng Lisa F P
Abstract excerpt
RNA-sensing toll-like receptors (TLRs) mediate innate immunity and regulate anti-viral response. We show here that TLR3 regulates host immunity and the loss of TLR3 aggravates pathology in Chikungunya virus (CHIKV) infection. Susceptibility to CHIKV infection is markedly increased in human and mouse fibroblasts with defective TLR3 signaling. Up to 100-fold increase in CHIKV load was observed in Tlr3-/- mice,...
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