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Article

TLR3 deficiency in herpes simplex encephalitis: high allelic heterogeneity and recurrence risk.

Neurology - 18 Nov 2014

Lim Hye Kyung, Seppänen Mikko, Hautala Timo, Ciancanelli Michael J, Itan Yuval, Lafaille Fabien G, Dell William, Lorenzo Lazaro, Byun Minji, Pauwels Elodie, Rönnelid Ylva, Cai Xin, Boucherit Soraya, Jouanguy Emmanuelle, Paetau Anders, Lebon Pierre, Rozenberg Flore, Tardieu Marc, Abel Laurent, Yildiran Alisan, Vergison Anne, Roivainen Reina, Etzioni Amos, Tienari Pentti J, Casanova Jean-Laurent, Zhang Shen-Ying

Abstract excerpt

OBJECTIVE: To determine the proportion of children with herpes simplex encephalitis (HSE) displaying TLR3 deficiency, the extent of TLR3 allelic heterogeneity, and the specific clinical features of TLR3 deficiency. METHODS: We determined the sequence of all exons of TLR3 in 110 of the 120 patients with HSE enrolled in our study who do not carry any of the previously described HSE-predisposing mutations of TLR3...

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Identifiers

PMID: 25339207
DOI: 10.1212/WNL.0000000000000999
PMCID: PMC4248460

Genes

TLR3
TBK1
TRAF3

Variants

Provenance

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