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Article

TLR3 immunity to infection in mice and humans.

Current opinion in immunology - 1 Feb 2013

Zhang Shen-Ying, Herman Melina, Ciancanelli Michael J, Pérez de Diego Rebeca, Sancho-Shimizu Vanessa, Abel Laurent, Casanova Jean-Laurent

Abstract excerpt

TLR3 is a receptor for dsRNA, which is generated during most viral infections. However, other cellular processes may also produce dsRNA and there are other receptors for dsRNA. The role of TLR3 in protective immunity to viruses has been investigated in mice and humans with genetically impaired TLR3 responses. TLR3-deficient mice responded to experimental challenge with 16 different viruses in various ways. They...

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Topics

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Share to Adaptor Proteins, Vesicular Transport
Share to Encephalitis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Herpesvirus 1, Human

Share to Immunity, Innate

Share to Mice, Knockout

Share to RNA, Double-Stranded

Share to Toll-Like Receptor 3

Share to Virus Diseases

Source

Open in PubMed Open full text

Identifiers

PMID: 23290562
DOI: 10.1016/j.coi.2012.11.001
PMCID: PMC3594520

Genes

TLR3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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