Article
Mutations in the TLR3 signaling pathway and beyond in adult patients with herpes simplex encephalitis.
Genes and immunity - 1 Dec 2015
Mørk N, Kofod-Olsen E, Sørensen K B, Bach E, Ørntoft T F, Østergaard L, Paludan S R, Christiansen M, Mogensen T H
Abstract excerpt
Herpes simplex encephalitis (HSE) in children has previously been linked to defects in type I interferon production downstream of Toll-like receptor (TLR)3. In the present study, we used whole-exome sequencing to investigate the genetic profile of 16 adult patients with a history of HSE. We identified novel mutations in IRF3, TYK2 and MAVS, molecules involved in generating innate antiviral immune responses, which...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.