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Article

TLR3 Mutations in Adult Patients With Herpes Simplex Virus and Varicella-Zoster Virus Encephalitis.

The Journal of infectious diseases - 1 May 2017

Sironi Manuela, Peri Anna Maria, Cagliani Rachele, Forni Diego, Riva Stefania, Biasin Mara, Clerici Mario, Gori Andrea

Abstract excerpt

Defects in genes of the Toll-like receptor 3 (TLR3) pathway are associated with susceptibility to herpes simplex virus type 1 encephalitis (HSE). We analyzed a cohort of 11 adult Italian patients in whom viral encephalitis developed. We detected 2 rare missense mutations in TLR3: 1 in a patient with HSE (p.Leu297Val) and 1 in a patient with varicella-zoster virus encephalitis (p.Leu199Phe). Both mutations are...

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Identifiers

PMID: 28368532
DOI: 10.1093/infdis/jix166

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TLR3

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