Human TRAF3 adaptor molecule deficiency leads to impaired Toll-like receptor 3 response and susceptibility to herpes simplex encephalitis.

doi:10.1016/j.immuni.2010.08.014

Article

Human TRAF3 adaptor molecule deficiency leads to impaired Toll-like receptor 3 response and susceptibility to herpes simplex encephalitis.

Immunity - 24 Sept 2010

Pérez de Diego Rebeca, Sancho-Shimizu Vanessa, Lorenzo Lazaro, Puel Anne, Plancoulaine Sabine, Picard Capucine, Herman Melina, Cardon Annabelle, Durandy Anne, Bustamante Jacinta, Vallabhapurapu Sivakumar, Bravo Jerónimo, Warnatz Klaus, Chaix Yves, Cascarrigny Françoise, Lebon Pierre, Rozenberg Flore, Karin Michael, Tardieu Marc, Al-Muhsen Saleh, Jouanguy Emmanuelle, Zhang Shen-Ying, Abel Laurent, Casanova Jean-Laurent

Abstract excerpt

Tumor necrosis factor (TNF) receptor-associated factor 3 (TRAF3) functions downstream of multiple TNF receptors and receptors that induce interferon-α (IFN-α), IFN-β, and IFN-λ production, including Toll-like receptor 3 (TLR3), which is deficient in some patients with herpes simplex virus-1 encep...

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Human TRAF3 adaptor molecule deficiency leads to impaired Toll-like receptor 3 response and susceptibility to herpes simplex encephalitis.

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