Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Pharmacogenetics of deoxycytidine kinase: identification and characterization of novel genetic variants.

The Journal of pharmacology and experimental therapeutics - 1 Dec 2007

Lamba Jatinder K, Crews Kristine, Pounds Stanley, Schuetz Erin G, Gresham Jessica, Gandhi Varsha, Plunkett William, Rubnitz Jeffrey, Ribeiro Raul

Abstract excerpt

Deoxycytidine kinase (DCK) is a rate-limiting enzyme in the activation of nucleoside analogs such as cytarabine (ara-C), gemcitabine, clofarabine, and others. The present study was undertaken to identify and to determine the functional consequences of genetic variants in DCK. We sequenced 1.5 kil...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antimetabolites, Antineoplastic
Share to Blotting, Western

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA, Complementary

Share to Drug Administration Schedule

Share to Leukemia, Myeloid, Acute

Share to Linkage Disequilibrium

Share to Pharmacogenetics

Share to Reverse Transcriptase Polymerase Chain Reaction

Source

Identifiers

PMID: 17855478
DOI: 10.1124/jpet.107.128595

Genes

DCK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17855478-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Pharmacogenetics of deoxycytidine kinase: identification and characterization of novel genetic variants.PMID 17855478Read ↗

Novel deoxycytidine kinase gene polymorphisms: a population screening study in Caucasian healthy volunteers.Semantic proximity Read ↗

Twenty novel genetic variations and haplotype structures of the DCK gene encoding human deoxycytidine kinase (dCK).Semantic proximity Read ↗

Association between DCK 35708 T>C variation and clinical outcomes of acute myeloid leukemia in South Chinese patients.Semantic proximity Read ↗

Gemcitabine pharmacogenomics: cytidine deaminase and deoxycytidylate deaminase gene resequencing and functional genomics.Semantic proximity Read ↗

Pharmacogenomics of gemcitabine metabolism: functional analysis of genetic variants in cytidine deaminase and deoxycytidine kinase.Semantic proximity Read ↗

Determination of common genetic variants in cytidine deaminase (CDA) gene in Indian ethnic population.Semantic proximity Read ↗

Identification of functional single nucleotide polymorphism haplotypes in the cytidine deaminase promoter.Semantic proximity Read ↗

Human cytidine deaminase: a biochemical characterization of its naturally occurring variants.Semantic proximity Read ↗

PCR-based methods for CDA K27Q and A70T genotyping: genotypes and alleles distribution in a central Italy population.Semantic proximity Read ↗

Association between single nucleotide polymorphisms in deoxycytidine kinase and treatment response among acute myeloid leukaemia patients.Semantic proximity Read ↗

Cytosolic 5'-nucleotidase III (NT5C3): gene sequence variation and functional genomics.Semantic proximity Read ↗

Rapid allele-specific PCR method for CDA 79A>C (K27Q) genotyping: a useful pharmacogenetic tool and world-wide polymorphism distribution.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.