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Article

Identification of functional single nucleotide polymorphism haplotypes in the cytidine deaminase promoter.

Human genetics - 1 Apr 2006

Fitzgerald Sara M, Goyal Rakesh K, Osborne William R A, Roy Jennifer D, Wilson John W, Ferrell R E

Abstract excerpt

Cytidine deaminase (CDA) hydrolytically deaminates and irreversibly deactivates the chemotherapeutic agent cytosine arabinoside (Ara-C), a deoxycytidine analog used for treatment of acute leukemias and lymphomas. To determine if single nucleotide polymorphisms (SNPs) in the promoter region of CDA affected gene expression, we sequenced approximately 1.6 Kb upstream of the CDA translation initiation site and...

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Source

Identifiers

PMID: 16446974
DOI: 10.1007/s00439-006-0142-0

Genes

CDA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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