Article
Cytosolic 5'-nucleotidase III (NT5C3): gene sequence variation and functional genomics.
Pharmacogenetics and genomics - 1 Aug 2009
Aksoy Pinar, Zhu Min Jia, Kalari Krishna R, Moon Irene, Pelleymounter Linda L, Eckloff Bruce W, Wieben Eric D, Yee Vivien C, Weinshilboum Richard M, Wang Liewei
Abstract excerpt
BACKGROUND: 5'-Nucleotidases play a critical role in nucleotide pool balance and in the metabolism of nucleoside analogs such as gemcitabine and cytosine arabinoside (AraC). We previously performed an expression array association study with gemcitabine and AraC cytotoxicity using 197 human lymphoblastoid cell lines. One gene that was significantly associated with gemcitabine cytotoxicity was a nucleotidase family...
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