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Article

Pharmacogenomics of gemcitabine metabolism: functional analysis of genetic variants in cytidine deaminase and deoxycytidine kinase.

Drug metabolism and disposition: the biological fate of chemicals - 1 Mar 2013

Baker Jessica A Roseberry, Wickremsinhe Enaksha R, Li Claire H, Oluyedun Olukayode A, Dantzig Anne H, Hall Stephen D, Qian Yue-Wei, Ring Barbara J, Wrighton Steven A, Guo Yingying

Abstract excerpt

Gemcitabine (dFdC, 2',2'-difluorodeoxycytidine) is metabolized by cytidine deaminase (CDA) and deoxycytidine kinase (DCK), but the contribution of genetic variation in these enzymes to the variability in systemic exposure and response observed in cancer patients is unclear. Wild-type enzymes and variants of CDA (Lys27Gln and Ala70Thr) and DCK (Ile24Val, Ala119Gly, and Pro122Ser) were expressed in and purified...

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Source

Identifiers

PMID: 23230131
DOI: 10.1124/dmd.112.048769

Genes

CDA
DCK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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