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A 100K genome-wide association scan for diabetes and related traits in the Framingham Heart Study: replication and integration with other genome-wide datasets.

Diabetes - 1 Dec 2007

Florez Jose C, Manning Alisa K, Dupuis Josée, McAteer Jarred, Irenze Kathryn, Gianniny Lauren, Mirel Daniel B, Fox Caroline S, Cupples L Adrienne, Meigs James B

Abstract excerpt

OBJECTIVE: To use genome-wide fixed marker arrays and improved analytical tools to detect genetic associations with type 2 diabetes in a carefully phenotyped human sample. RESEARCH DESIGN AND METHODS: A total of 1,087 Framingham Heart Study (FHS) family members were genotyped on the Affymetrix 100K single nucleotide polymorphism (SNP) array and examined for association with incident diabetes and six...

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PMID: 17848626
DOI: 10.2337/db07-0451

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