Article
Confirmation of multiple risk Loci and genetic impacts by a genome-wide association study of type 2 diabetes in the Japanese population.
Diabetes - 1 Jul 2009
Takeuchi Fumihiko, Serizawa Masakuni, Yamamoto Ken, Fujisawa Tomomi, Nakashima Eitaro, Ohnaka Keizo, Ikegami Hiroshi, Sugiyama Takao, Katsuya Tomohiro, Miyagishi Makoto, Nakashima Naoki, Nawata Hajime, Nakamura Jiro, Kono Suminori, Takayanagi Ryoichi, Kato Norihiro
Abstract excerpt
OBJECTIVE: To identify novel type 2 diabetes gene variants and confirm previously identified ones, a three-staged genome-wide association study was performed in the Japanese population. RESEARCH DESIGN AND METHODS: In the stage 1 scan, we genotyped 519 case and 503 control subjects with 482,625 single nucleotide polymorphism (SNP) markers; in the stage 2 panel comprising 1,110 case subjects and 1,014 control...
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